Wellness Institute for Sleep & Health
“Level” is a packaging convention, not a fixed weekly-dose mandate — here’s what it actually means, and the flexibility it gives you.
For both medications WISH prescribes, “Level” mostly reflects the volume of your vial, not a different medication strength — the concentration stays the same across most levels, and only the amount you draw up changes.
Levels 1 through 4 are all the same 10mg/mL concentration — only the vial volume increases. Level 5 is a genuinely different, higher concentration.
| Level | Concentration | Vial Volume | Nominal Weekly Dose | Fill Syringe To |
|---|---|---|---|---|
| Level 1 (Starter) | 10mg/mL | 1mL | 2.5mg/week | 25 units |
| Level 2 | 10mg/mL | 2mL | 5mg/week | 50 units |
| Level 3 | 10mg/mL | 3mL | 7.5mg/week | 75 units |
| Level 4 | 10mg/mL | 4mL | 10mg/week | 100 units |
| Level 5 (Forte) | 15mg/mL | 4mL | 15mg/week | 100 units |
Same pattern as tirzepatide: Levels 1 through 4 are all the same 2.5mg/mL concentration, only the vial volume increases. Level 5 DS is the outlier, with a genuinely higher concentration.
| Level | Concentration | Vial Volume | Nominal Weekly Dose | Fill Syringe To |
|---|---|---|---|---|
| Level 1 (Starter) | 2.5mg/mL | 1mL | 0.625mg/week | 25 units |
| Level 2 | 2.5mg/mL | 2mL | 1.25mg/week | 50 units |
| Level 3 | 2.5mg/mL | 3mL | 1.875mg/week | 75 units |
| Level 4 | 2.5mg/mL | 4mL | 2.5mg/week | 100 units |
| Level 5 DS | 5mg/mL | 3mL | 3.75mg/week | 75 units |
Reading “Fill Syringe To”: your syringes are standard insulin syringes, marked in “units” (100 units = 1mL, regardless of the syringe’s total capacity). Whether you have a 0.3mL, 0.5mL, or 1mL syringe from your kit, the unit markings mean the same thing — fill to the unit number shown above for your Level, not to a fraction of the barrel. Syringes and needles are included with every order, not just your first. For step-by-step preparation and injection technique, see our Storage & Injection guide.
Because a higher “Level” is mostly just more volume at the same concentration, it’s possible to buy a higher-Level vial and choose to inject at a lower, longer-lasting rate than the label’s nominal weekly dose implies — see below.
Yes — if it’s approved by your physician. Because concentration stays constant across Levels 1–4, you have real flexibility in how you use a given vial.
Worked example — tirzepatide: say you’re prescribed a Level 2 vial (10mg/mL, 2mL total, nominally 5mg/week). Instead of drawing 50 units each week, your physician might have you draw 25 units (the Level 1 rate) instead. The same 2mL vial that was meant to last 4 weeks at Level 2 now lasts roughly 8 weeks at Level 1 — same vial, same cost, effectively half the weekly dose and double the duration.
Worked example — semaglutide: a Level 3 vial (2.5mg/mL, 3mL, nominally 1.875mg/week, 75 units) could instead be drawn at 25 units/week (the Level 1 rate) if your physician determines that’s the right fit for you — stretching that vial from a 4-week supply to roughly 12 weeks.
This isn’t a DIY instruction to change your own dose — it’s something to raise with your physician at your next refill, so any change is guided and documented as part of your ongoing care.
Always physician-guided. This page explains how the packaging works so you understand your options — it isn’t a substitute for discussing a dose change with your physician.
Not necessarily — and escalating “just because” isn’t the goal.
Every patient responds differently at every Level. Some patients see strong appetite control and steady progress at Level 1 and never need to move higher; others need Level 3 or 4 to get the same effect. Neither is better or worse — what matters is whether your current Level is working for you, not whether you’ve “kept pace” with some expected schedule.
A good general rule: if a Level is working — you’re tolerating it well and seeing progress — there’s rarely a reason to escalate just for the sake of it. Consider bringing up an increase with your physician at your next refill if progress has genuinely stalled despite good adherence, or if side effects were the main reason you were hesitant to increase and those have since resolved. Consider a decrease if side effects are hard to manage even after the usual strategies, or if you’ve reached a level of results you’re happy maintaining. Either direction is a conversation for your refill, not something to decide alone.
Do I have to increase my dose over time?
No. There’s no fixed schedule — many patients stay at one Level indefinitely if it’s working. Dose changes are always discussed at a refill, never automatic.
What if I inject more than planned and my vial runs out early?
Contact us before your next scheduled refill date — we can help you plan your next order so you’re not without medication. Don’t skip doses to stretch a vial without checking with your physician first.
Bring it up at your next refill, or reach us anytime at [email protected].
